(1) Medical field
Drug intermediates:
1. Used for synthesizing antibacterial drugs (such as the piperazine ring fragment of quinolone antibiotics, similar to the structural unit of norfloxacin).
2. Construct central nervous system (CNS) drugs (such as antidepressants or 5-HT receptor modulators).
3. Participate in the design of anticancer drugs (such as modifying the piperazine ring in kinase inhibitors).
(2) Organic synthesis
Multi functional reactivity:
1. The ester group can be hydrolyzed to carboxylic acid (2-piperazinecarboxylic acid) or reduced to alcohol for further derivatization.
2. The nitrogen atom of piperazine can be alkylated or acylated to construct complex molecules (such as multi-target drugs).
Chiral synthesis: used as a precursor for chiral piperazine rings in asymmetric catalytic reactions.
(3) Pesticides and materials
Pesticide intermediates: used as nitrogen-containing heterocyclic frameworks in the synthesis of a few insecticides or fungicides.
Coordination chemistry: forms complexes with metal ions (such as palladium and copper) for catalytic reactions.
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