Pharmaceutical intermediates:
1. Used for synthesizing anti tuberculosis drugs (such as pyrazinamide derivatives) and anti-tumor compounds
2. Participate in multi-step organic synthesis as a heterocyclic block

Spices and food additives:
1. Pyrazine lipids are key components of food flavor agents (such as barbecue, nut essence)

Organic synthesis reagents:
1. Preparation of 2-pyrazine formic acid or 2-pyrazine formamide through hydrolysis or ammonolysis reaction