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1-Boc-3-hydroxypiperidine

Product name 1-Boc-3-hydroxypiperidine,
tert-butyl 3-hydroxypiperidine-1-carboxylate,
1-n-boc-3-hydroxy-piperidine
CAS No. 85275-45-2
Molecular formula C10H19NO3
Use

Drug synthesis protective group:
1. The BOC group (tert butoxycarbonyl) can protect the nitrogen atom of the pyridine ring, prevent side reactions in multi-step synthesis, and finally deprotect it through acid (such as TFA).
2. Piperidinol structural fragments used for constructing CNS drugs (such as antidepressants and analgesics).
3. Participate in the synthesis of key intermediates for anticancer drugs, such as kinase inhibitors or proteasome inhibitors.

Selective modification of functional groups:
1. Hydroxyl groups can undergo oxidation, esterification, or etherification reactions independently, while BOC protects nitrogen atoms from being affected.
2. As a chiral synthesizer, it is used for asymmetric synthesis (such as the preparation of chiral pyridine compounds).

Ligand design: nitrogen-containing ligands used for metal catalyzed reactions (such as palladium and copper complexes).

Peptide mimetics: constructing rigid pyridine ring structures in peptidomimetic molecules.

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