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3-Hydroxypiperidine

Product name 3-Hydroxypiperidine,
3-Hydroxyhexahydropyridine,
Piperidin-3-ol
CAS No. 6859-99-0
Molecular formula C5H11NO
Use

Drug intermediates:
1. Used for synthesizing central nervous system (CNS) drugs, such as antidepressants, anxiolytics, or analgesics (by synergistically regulating receptor activity through hydroxyl and pyridine rings).
2. Build the key backbone of antipsychotic drugs (such as dopamine D ₂ receptor antagonists).
3. Participate in the design of anti-cancer drugs (such as modifying groups of topoisomerase inhibitors or kinase inhibitors).

Organic synthesis:
1. Functional group conversion: Hydroxyl groups can be oxidized to ketones (3-piperidinone) or derived into ethers/esters, expanding molecular diversity. As a chiral synthesizer, it is used for asymmetric catalytic reactions (such as asymmetric hydrogenation of pyridine rings).
2. Protective chemistry: Hydroxyl groups can be protected by silicon ethers or benzyl groups for multi-step synthesis.

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